€615.00 €522.75
Tropomyosin-related kinase A (TrkA), TrkB, and TrkC are transmembrane receptors that are encoded by NTRK1, NTRK2, and NTRK3, respectively, in humans with roles in neuronal cell differentiation and survival, synaptic formation and plasticity, memory formation and retention, proprioception, and nociception.{64184,64183} They are composed of an extracellular domain containing two cysteine-rich clusters, three Trk-specific leucine-rich repeats, and two immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain.{64183} Trks are expressed in neuronal tissue and have essential roles in embryonic development and nervous system function. Binding of neurotrophins to Trks induces receptor dimerization and autophosphorylation. This induces activation of the intracellular kinase domain, enabling docking of cytoplasmic adaptor proteins and enzymes to facilitate downstream intracellular signaling events via the ERK/MAPK, PI3K, and PLC? pathways. Loss-of-function mutations in NTRK1 are associated with autonomic and sensory neuronal disorders, such as congenital insensitivity to pain with anhidrosis, while loss-of-function mutations in NTRK2 are associated with loss of appetite control, obesity, and defects in learning and memory. NTRK3-ETV6 gene fusions are pathognomonic in infantile fibrosarcoma and congenital mesoblastic nephroma.{64183,64185} Cayman’s pan-Trk (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide from the C-terminal region of human Trk |
| Clone | RM423 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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