sPLA2 (human, recombinant type IIA)
sPLA2 (human, recombinant type IIA)
Secretory phospholipase A2 (sPLA2) (Type IIA) is a calcium-dependent PLA2 superfamily member that is encoded by PLA2G2A in humans.{56210} It...
From €248.00 €210.80
8-iso PGF2?-d4 is intended for use as an internal standard for the quantification of 8-iso PGF2? by GC- or LC-mass spectrometry. 8-iso Prostaglandin F2? (8-iso PGF2?) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.{320,371,855} It circulates in human plasma in two distinct forms – esterified in LDL phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2? level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2? levels are about 180-200 pg/mg of creatinine.{320,371} 8-iso PGF2? is a weak TP receptor agonist in vascular smooth muscle.{6640} Conversely, 8-iso PGF2? inhibits platelet aggregation induced by U-46619 (10?6 M) and I-BOP (3 x 10?7 M) with IC50 values of 1.6 x 10?6 M and 1.8 x 10?6 M, respectively.{855}
Territorial Availability: Available through Bertin Technologies only in France
Size | 100 µg, 25 µg, 50 µg |
---|---|
Shipping | dry ice |
CAS number | 211105-40-7 |
Molecular formula | C20H30D4O5 |
Smiles | O[C@@H]1[C@@H](C/C=CC([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)[C@H](O)C1, O[C@@H]1[C@@H](C/C=CC([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)[C@H](O)C1, O[C@@H]1[C@@H](C/C=CC([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)[C@H](O)C1 |
Molecular weight | 358,5 |
Custom code | 3822.19 |
Formulation | A solution in methyl acetate |
Purity | ≥99% deuterated forms (d1-d4) |
UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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