β-Mangostin
β-Mangostin
β-Mangostin is a xanthone originally isolated from G. mangostana with diverse biological activites.{39821,39822,39823,39824,39825,39826} It inhibits growth of methicillin-resistant S. aureus...
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γ-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities.{48253,48254,48255,48256} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro with an IC50 value of 23.6 μM.{48253} γ-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively).{48254} It inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages in a concentration-dependent manner.{48255} Macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 μM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes. γ-Mangostin (5 and 10 mg/kg) inhibits carbon tetrachloride-induced increases in serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) and decreases in hepatic superoxide dismutase 2 (SOD2) activity and glutathione (GSH) content in a mouse model of liver fibrosis.{48256}
Territorial Availability: Available through Bertin Technologies only in France
Size | 10 mg, 25 mg, 5 mg, 50 mg |
---|---|
Shipping | dry ice |
CAS Number | 31271-07-5 |
Molecular Formula | C23H24O6 |
SMILES | OC1=C2C(OC(C=C(O)C(O)=C3C/C=C(C)/C)=C3C2=O)=CC(O)=C1C/C=C(C)/C |
Molecular Weight | 396,4 |
Formulation | A crystalline solid |
Purity | ≥98% |
Custom Code | 2907.29 |
UNSPSC code | 12352100 |
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