PKF118-310

PKF118-310

CAT N°: 22440
Price:

48.00 40.80

PKF118-310 is an inhibitor of the protein-protein interaction between T cell factor 4 (Tcf4) and ?-catenin that is produced by Actinomycete strains.{40755} It disrupts binding of ?-catenin to a GST-Tcf4 fusion protein in HCT116 cell lysates (IC50 = 0.8 µM). PKF118-310 blocks appearance of the Tcf4 and ?-catenin complex bound to DNA in an EMSA assay. It reduces levels of the ?-catenin regulated proteins c-Myc and cyclin D1 but has no effect on cyclin E in HCT116 cells. PKF118-310 (0.5 pmol) abrogates ?-catenin, but not siamois, ventral body axis duplication induced by mRNA in Xenopus embryos. It reduces growth of HCT116, HT-29, PC3, and DU145 cancer cells in vitro (IC50s = 170-300 nM). PKF118-310 (1 mg/kg twice per week) reduces tumor growth and expression of c-Myc, cyclin D1, and Survivin in a HepG2 mouse xenograft model.{40756}

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