KIN1408

KIN1408

CAT N°: 21790
Price:

140.00 119.00

KIN1408 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity.{41564} It induces interferon regulatory factor 3 (IRF3) activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity. KIN1408 induces expression of the innate immune genes MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA; Item No. 10008014). It exhibits concentration-dependent broad-spectrum antiviral activity against dengue virus 2 as well as the influenza A, Ebola, Nipah, and Lassa viruses.

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