ST034307

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ST034307

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Cat No: 21777

Biochemicals - Small Molecule Inhibitors

ST034307 is an inhibitor of adenylyl cyclase 1 (AC1), a membrane-bound AC, with an IC50 value of 2.3 µM for A23187-stimulated cAMP accumulation in HEK293 cells transfected with AC1.{38508} It also inhibits AC1 activation induced by forskolin (Item No....

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6-chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one

Correlated keywords:

ST-034307 AC-1 HEK-293 adenylylcyclase A-23187

Product Overview:
ST034307 is an inhibitor of adenylyl cyclase 1 (AC1), a membrane-bound AC, with an IC50 value of 2.3 µM for A23187-stimulated cAMP accumulation in HEK293 cells transfected with AC1.{38508} It also inhibits AC1 activation induced by forskolin (Item No. 11018) or isoproterenol (Item No. 15592) in vitro. It is selective for AC1 over other membrane-bound AC isoforms. ST034307 enhances the inhibition of AC1 by the µ-opioid receptor (MOR) agonist DAMGO (Item No. 21553) in HEK293 cells transfected with AC1 and MOR. In a mouse model of inflammatory pain, ST034307 reduces hypersensitivity to touch in mouse hind paw (ED50 = 0.28 µg), which is blocked by forskolin.

Size	1 mg
Shipping	dry ice
CAS Number	133406-29-8
Molecular Formula	C₁₀H₄Cl₄O₂
SMILES	O=C1C2=CC(Cl)=CC=C2OC(C(Cl)(Cl)Cl)=C1
Molecular Weight	298
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.