Vatalanib (hydrochloride)

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Cat No: 14868

Biochemicals - Kinase Inhibitors

Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively.{24346,24345} It less potently inhibits PDGF an...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, dihydrochloride

Correlated keywords:

inhibitors inhibits inhibitions receptors antagonists cancers angiogenesis diabetes proteins kinases signals transduction angiogenesis potent selective VEGFs tyrosine VEGFRs VEGFR1 VEGFR-1 1 one VEGFR2 VEGFR-2 2 two VEGFR3 VEGFR-3 3 three Flt1 Flt-1 Flts KDRs Flt-4 Flt4 four 4 retinal neovascularization retinopathy aberrant vascular CGPs 79787 CGP-79787 CGP79787 ZKs 222584 ZK-222584 ZK222584 PTKs PTK-787 PTK787 PTKZK PTK/ZK ZK 212141-54-3

Product Overview:
Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively.{24346,24345} It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases.{24346,24344,24345} Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.{18281,24343}

Size	10 mg
Shipping	dry ice
CAS Number	212141-51-0
Molecular Formula	C₂₀H₁₅ClN₄ • 2HCl
SMILES	ClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42.Cl.Cl
Molecular Weight	419,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.