Celecoxib

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Celecoxib

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Cat No: 10008672

Biochemicals - Small Molecule Inhibitors

Celecoxib is a selective inhibitor of COX-2 (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively).{11633,8926} In vivo, celecoxib (0.3 ml of a 0.4% solution) administered intra-articularly reduces production of IL-1β, TNF-α, and MMP-3 as well a...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

Correlated keywords:

anti-inflammatory diaryl heterocycle inhibit COXs COX2 2 two cyclooxygenases cyclooxygenase-2 COX-2 antitumors anti-tumors antiinflammatory apoptosis selective therapeutic NSAID sulfonamide nonsteroidal YM 177 YMs 177 YM177 SC58635 SC 58635 SCs 58635 eurocox medicoxib apopeotsis non-steroidal Celebra Celebrex Onsenal Xilebao?

Product Overview:
Celecoxib is a selective inhibitor of COX-2 (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively).{11633,8926} In vivo, celecoxib (0.3 ml of a 0.4% solution) administered intra-articularly reduces production of IL-1β, TNF-α, and MMP-3 as well as articular cartilage damage in a rabbit model of osteoarthritis.{41721} It reduces blood glucose and improves renal function and memory deficits via downregulation of COX-2 expression and increased BDNF -TrkB signaling in rats with diabetes induced by streptozotocin (Item No. 13104).{41722} Celecoxib also displays chemopreventive activity in multiple tumor types via proapoptotic effects that are independent of COX-2 inhibition.{12660,11712,13638} Formulations containing celecoxib have been used in the treatment of inflammation while circumventing the gastrointestinal toxicity associated with traditional non-steroidal anti-inflammatory drugs, however, the use of celecoxib has been tempered due to its ability to induce adverse cardiovascular events.{14766}

Size	50 mg
Shipping	dry ice
CAS Number	169590-42-5
Molecular Formula	C₁₇H₁₄F₃N₃O₂S
SMILES	NS(C1=CC=C(N2C(C3=CC=C(C)C=C3)=CC(C(F)(F)F)=N2)C=C1)(=O)=O
Molecular Weight	381,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.