Prostaglandin A2-biotin

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Prostaglandin A₂-biotin

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Cat No: 10010499

Prostaglandin A2 (PGA2) blocks cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase.{2678} It has antitumor effects, targeting scaffold/matrix attachment region-binding protein 1 (SMAR1) through an Hsp70-dependent mechanism.{335,18712,18809...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9-oxo-15S-hydroxy-prosta-5Z,10,13E-trien-1-oyl-N’-biotinoyl-1,5-diaminopentane

Correlated keywords:

affinity probes cancer apoptosis cells cycles biotins biotinamides biotinimides biotinylateds ligands receptors thromboxanes A2 prostaglandins H2 EP4 subtypes EP3 EP2 EP1 E2 PGE prostanoids TXA2-PGH2 TXA2 PGH2 PGE2 PGs

Product Overview:
Prostaglandin A2 (PGA2) blocks cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase.{2678} It has antitumor effects, targeting scaffold/matrix attachment region-binding protein 1 (SMAR1) through an Hsp70-dependent mechanism.{335,18712,18809} PGA2 also induces apoptosis in HL-60 cells.{18713} Prostaglandin A2-biotin (PGA2-biotin) is an affinity probe which allows PGA2 to be detected through an interaction with the biotin ligand. Biotinylated eicosanoids have been used to capture proteins which interact with the lipid.{6482}

Size	100 µg
Shipping	dry ice
Molecular Formula	C₃₅H₅₆N₄O₅S
SMILES	O=C1C=C[C@H](/C=C/[C@@H](O)CCCCC)[C@H]1C/C=C\CCCC(NCCCCCNC(CCCC[C@H]2SC[C@@](N3)([H])[C@]2([H])NC3=O)=O)=O
Molecular Weight	644,9
Formulation	A solution in ethanol
Purity	≥95%
Custom Code	2937.50
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.