?-Nicotinamide Mononucleotide

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Cat No: 16411

Biochemicals - More Biochemicals

β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+; Item No. 16077). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(aminocarbonyl)-1-(5-O-phosphono-?-D-ribofuranosyl)-pyridinium, inner salt

Correlated keywords:

27626-81-9 1140909-84-7 intermediate biosynthesis nicotinamide adenine dinucleotide NAD+ Nicotinamide phosphoribosyltransferase Nampt visfatin glucose insulin metabolism metabolic disease type 2 diabetes biochemical syndrome obesity ?-NMN ?NMN catalyze condensation 5-phosphoribosyl-1-pyrophosphate adenyltransferase biosynthesis glucose-stimulated secretion mouse mice model cell function ameliorate intolerance high-fat diet-induced level ribonucleoside 5'-phosphate ribotide ?-D-NMN ribose monophosphate

Product Overview:
β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+; Item No. 16077). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.{19182} At 50-100 µM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.{19185} Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.{20366}

Size	10 mg
Shipping	dry ice
CAS Number	1094-61-7
Molecular Formula	C₁₁H₁₅N₂O₈P
SMILES	O[C@H]1[C@@H](O)[C@H]([N+]2=CC(C(N)=O)=CC=C2)O[C@@H]1COP(O)([O-])=O
Molecular Weight	334,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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