N-Desethylamiodarone (hydrochloride)

Biochemicals - Ion Channel Modulation

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Cat No: 9000537

Biochemicals - Ion Channel Modulation

Amiodarone (Item No. 15213) is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2-butyl-3-benzofuranyl)[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]-methanone, monohydrochloride

Correlated keywords:

substrate CYP3A4 metabolite amiodarone cytochromes CYP-3A4 analytical reference standard antiarrhythmic cardiology biochemical metabolism cytochrome P450 P 450

Product Overview:
Amiodarone (Item No. 15213) is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.{24593} In humans, cytochrome P450 3A is involved in the metabolism of amiodarone.{29074} N-Desethylamiodarone is the major, active metabolite of amiodarone. This compound has been used as an analytical reference standard for quantifying amiodarone in plasma samples.{29075}

Size	10 mg
Shipping	dry ice
CAS Number	96027-74-6
Molecular Formula	C₂₃H₂₅I₂NO₃ • HCl
SMILES	CCCCC1=C(C(C2=CC(I)=C(OCCNCC)C(I)=C2)=O)C3=CC=CC=C3O1.Cl
Molecular Weight	653,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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