AZD 4635

AZD 4635

CAT N°: 26322
Price:

203.00 172.55

AZD 4635 is an adenosine A2 receptor antagonist (Ki = 1.7 nM for the human receptor).{47334} It inhibits adenosine-induced cAMP production in CHO cells expressing the human A2 receptor (IC50 = 0.79 ?M) and reverses suppression of IFN-? secretion induced by 5′-N-ethylcarboxamidoadenosine (NECA; Item No. 21420) in CD8+ T cells. AZD 4635 reduces tumor growth when administered alone and in combination with checkpoint inhibitors in syngeneic mouse tumor models.

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