Columbin

Columbin

CAT N°: 24105
Price:

66.00 56.10

Columbin is a diterpenoid furanolactone isolated from J. columba, A. albida, and T. bakis that has diverse biological activities.{38835,38836,38837,38838} It inhibits the growth of T. brucei in vitro and induces complete parasite clearance in T. brucei-infected mice when administered at a dose of 25 mg/kg per day for three days.{38835} Columbin selectively inhibits COX-2 over COX-1 (EC50s = 53.1 and 327 ?M, respectively) and reduces carrageenan-induced paw edema in rats in a dose-dependent manner.{38836} Dietary feeding of columbin (4, 20, and 100 ppm) reduces the number of lesions in a rat model of azoxymethane-induced colon carcinogenesis.{38837} Columbin (20-40 mg/kg per day) also reduces sleeping time induced by a mixture of urethane and ?-choralose but prolongs sleeping time induced by hexobarbital in mice.{38838}

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