Ziconotide (trifluoro<wbr/>acetate salt)

Ziconotide (trifluoroacetate salt)

CAT N°: 23913
Price:

385.00 327.25

Ziconotide is a synthetic version of ?-conopeptide MVIIA, a peptide toxin originally found in the venom of the fish-eating marine snail C. magus, that blocks N-type calcium channels in rat brain membranes (Kds = 1.1-18 pM; IC50s = 2-55 pM).{37354},{37355} It blocks high-voltage-activated calcium currents in rat superior cervical ganglion neurons (IC50 = 32 nM) as well as depolarization-induced norepinephrine release by rat peripheral sympathetic efferent neurons and in rat hippocampus (IC50s = 1.2 and 5.5 nM, respectively).{37354} Intrathecal administration of ziconotide inhibits formalin-induced flinch responses and increases the paw withdrawal threshold in the paw pressure test in rats (ED50s = 0.11 and 0.60 ?g, respectively), indicating antinociceptive effects.{37356} It decreases latency to tail withdrawal in a hot plate test in a rat model of sciatic chronic constriction injury.{37354} Ziconotide also reduces infarct volume post ischemia in a rat model of transient focal ischemia.{37357}

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