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Salvinorin B

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    Salvinorin B
  • Salvinorin B
Cat No: 23582
Biochemicals - Receptor Pharmacology
Cayman

Salvinorin B is the major deacetylated metabolite of salvinorin A (Item No. 11487).{36003,34652} It reportedly lacks pharmacological activity in vitro and in vivo when used in unperturbed systems. It binds as an agonist at the κ-opioid receptor (Ki = ...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid, methyl ester
Correlated keywords:
  • SIM1Cre SIM-1 anti-nociceptive
Product Overview:
Salvinorin B is the major deacetylated metabolite of salvinorin A (Item No. 11487).{36003,34652} It reportedly lacks pharmacological activity in vitro and in vivo when used in unperturbed systems. It binds as an agonist at the κ-opioid receptor (Ki = 2,950 nM; EC50 = 248 nM) but does not elicit antinociceptive effects even after i.c.v. administration. However, salvinorin B is a ligand for the inhibitory G protein-coupled κ-opioid designer receptor exclusively activated by designer drugs (DREADD; KORD; EC50s = 11.8 and 160 nM with high or low levels of KORD expression, respectively).{38358} It leads to hyperpolarization and inhibition of neuronal firing in neurons expressing KORD and has no effect on neurons transduced with mCherry as a control. Salvinorin B increases locomotor activity in VGAT-ires-Cre mice expressing KORD in the ventral tegmental area and substantia nigra, increases food intake in SIM1-Cre mice expressing KORD in the paraventricular hypothalamus, and decreases food intake in AGRP-ires-Cre mice expressing KORD in the arcuate nucleus. Salvinorin B can be used in combination with clozapine N-oxide (CNO; Item No. 16882) because it is inactive at Gq-based DREADDs. Salvinorin B is also available as an analytical reference standard (Item No. 11488).
Size 1 mg
Shipping dry ice
CAS Number 92545-30-7
Molecular Formula C21H26O7
SMILES O=C1[C@]2([H])CC[C@@]([C@@]3([H])[C@@]2(C)C[C@@H](C4=COC=C4)O1)(C)[C@H](C(OC)=O)C[C@H](O)C3=O
Molecular Weight 390,4
Formulation A crystalline solid
Purity ≥95%
Custom Code 2932.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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