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  • Colistin
Cat No: 23487
Biochemicals - Anti-Infection
Price is excluding VAT and does not include packaging neither shipping

Colistin is a complex antibiotic containing greater than 30 components, with the cyclic polypeptide antibiotics polymyxins E1 (colistin A) and E2 (colistin B) as the major components.{40859,43058} It was originally isolated from B. polymyxa.{40859} Co...


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Territorial Availability: Available through Bertin Pharma only in Europe
Correlated keywords:
  • 1393-79-9 1404-31-5 12643-15-1 7239-48-7 7722-44-3 Totazina Kangdisu Coly-Mycin Colivet Colisticina Bacillus Escherichia Pseudomonas Salmonella Listeria Lactococcus Paenibacillus Pediococcus Staphylococcus Klebsiella Acinetobacter anti-biotic E-1 2 lipopolysaccharide
Product Overview:
Colistin is a complex antibiotic containing greater than 30 components, with the cyclic polypeptide antibiotics polymyxins E1 (colistin A) and E2 (colistin B) as the major components.{40859,43058} It was originally isolated from B. polymyxa.{40859} Colistin inhibits the growth of the Gram-negative bacteria E. coli, P. aeruginosa, P. fluorescens, and S. enterica (MICs = 0.04-2.08 μg/ml) and Gram-positive L. ivanovii and L. monocytogenes (MICs = 2.5-10 μg/ml) but is not active against Gram-positive L. lactis, P. polymyxa, P. acidilactici, or S. aureus at concentrations up to 5 μg/ml.{40860} It also inhibits the growth of clinical isolates of both susceptible and multidrug-resistant P. aeruginosa (MICs = 1-2 mg/l).{40861} Colistin binds selectively to LPS from susceptible strains of K. pneumoniae compared to resistant strains (Kis = 0.56 and 2.83 μM, respectively), which may contribute to its mechanism of action against Gram-negative bacteria.{40863} In vivo, colistin slows the growth of P. aeruginosa and A. baumannii in a neutropenic mouse model of thigh infection.{40862}
Size 25 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 1066-17-7
Molecular Formula C53H100N16O13 (for E1)
SMILES O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCNC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC1=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)CCN)=O)=O)=O)CCN)=O)[C@H](O)C)=O)CCN)CCCC[C@@H](C)CC.CC(C)CCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CCNC([C@H
Molecular Weight 1169,5
Formulation A solid
Purity ≥95%
Custom Code 2924.19
UNSPSC code 12352100

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