CGP 3466 (maleate)

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CGP 3466 (maleate)

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Cat No: 23362

Biochemicals - More Biochemicals

CGP 3466 is a GAPDH ligand.{37164,37165} Immobilized CGP 3466 binds to GAPDH from rat hippocampus extracts and to purified recombinant rabbit muscle GAPDH using affinity purification.{37165} CGP 3466 reduces PAJU cell apoptosis induced by rotenone (It...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-methyl-N-2-propyn-1-yl-dibenz[b,f]oxepin-10-methanamine, (2Z)-2-butenedioate

Correlated keywords:

634202-78-1 181296-84-4 CGP3466B Tch346 PC-12 6OHDA CGP3466 Tch-346 Glyceraldehyde 3-phosphate dehydrogenase omigapil oxidopamine hydroxydopamine hydroxy-dopamine

Product Overview:
CGP 3466 is a GAPDH ligand.{37164,37165} Immobilized CGP 3466 binds to GAPDH from rat hippocampus extracts and to purified recombinant rabbit muscle GAPDH using affinity purification.{37165} CGP 3466 reduces PAJU cell apoptosis induced by rotenone (Item No. 13995). CGP 3466 dose-dependently increases survival of trophically withdrawn PC12 cells, decreases cytosine arabinoside-induced apoptosis of cerebellar granule cells, and increases the number of tyrosine hydroxylase-positive (TH+) mesencephalic dopaminergic neurons in vitro.{37164} Oral administration of CGP 3466 (0.14 mg/kg) increases the number of TH+ dopaminergic neurons in a rat model of Parkinson's disease induced by MPTP. It also reduces delayed acquisition in the Morris maze in a 6-OHDA-treated rat model of Parkinson's disease and increases survival in progressive motor neuronopathy (pmn) mice, a genetic model of amyotrophic lateral sclerosis (ALS). Formulations containing CGP 3466 are under clinical investigation for the treatment of Parkinson’s disease and ALS.{37166,37167}

Size	1 mg
Shipping	dry ice
CAS Number	200189-97-5
Molecular Formula	C₁₉H₁₇NO • C₄H₄O₄
SMILES	CN(CC#C)CC1=CC2=CC=CC=C2OC3=C1C=CC=C3.OC(/C=C\C(O)=O)=O
Molecular Weight	391,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.