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Valrubicin

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    Valrubicin
  • Valrubicin
Cat No: 22964
Cayman

Valrubicin is a semisynthetic anthracycline antitumor antibiotic and derivative of doxorubicin (Item No. 15007).{40337} It inhibits the growth of human bladder tumor cell lines with LD50 values ranging from 0.05 to 11.2 μM.{40339} Valrubicin is more...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • pentanoic acid, 2-[(2S,4S)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-2-naphthacenyl]-2-oxoethyl ester
Correlated keywords:
  • 136816-53-0 AD 32 AD32 Trifluoroacetyldoxorubicin NSC246131 Valstar Trifluoro acetyl doxorubicin CUB2 P 388 L 1210 smei-synthetic anti-tumor biotic
Product Overview:
Valrubicin is a semisynthetic anthracycline antitumor antibiotic and derivative of doxorubicin (Item No. 15007).{40337} It inhibits the growth of human bladder tumor cell lines with LD50 values ranging from 0.05 to 11.2 μM.{40339} Valrubicin is more active against cells in the plateau growth phase than in the log growth phase (LD70s = 2.5 and 12.1 μM, respectively for CUB-2 cells). Valrubicin (40 mg/kg) increases survival in mice with murine P388 and L1210 leukemias.{40337} Topical administration of valrubicin (0.01 g/ml) reduces epidermal thickness and normalizes epidermal morphology in a mouse psoriasis xenograft transplantation model.{40338} Formulations containing valrubicin have been used in the treatment of bladder cancer.
Size 500 µg
Shipping dry ice
CAS Number 56124-62-0
Molecular Formula C34H36F3NO13
SMILES OC1=C(C[C@](C(COC(CCCC)=O)=O)(O)C[C@@H]2O[C@@](O[C@@H](C)[C@H]3O)([H])C[C@@H]3NC(C(F)(F)F)=O)C2=C(O)C(C4=O)=C1C(C5=CC=CC(OC)=C45)=O
Molecular Weight 723,6
Formulation A crystalline solid
Purity ≥98%
Custom Code 2907.29
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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