11-deoxy Corticosterone

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Cat No: 22916

Biochemicals - Lipids

11-deoxy Corticosterone (DOC) is an endogenous mineralocorticoid synthesized in the zona fasciculata and zona glomerulosa of the adrenal gland.{41026} It is a metabolite of progesterone (Item No. 15876) and precursor to aldosterone (Item No. 15273) an...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

21-hydroxy-pregn-4-ene-3,20-dione

Correlated keywords:

30598-81-3 deoxycorticosterone 21-hydroxypregn-4-ene-3,20-dione dehydroxycorticosterone desoxycorticosterone 21-hydroxy-3,20-dioxopregn-4-ene pregnane pregnene hydroxyprogesterone Cortexone deoxycortone desoxycorticosterone desoxycortone Kendall's desoxy compound B NSC11319 Reichstein's substance Q ?4-Pregnene-21-ol-3,20-dione

Product Overview:
11-deoxy Corticosterone (DOC) is an endogenous mineralocorticoid synthesized in the zona fasciculata and zona glomerulosa of the adrenal gland.{41026} It is a metabolite of progesterone (Item No. 15876) and precursor to aldosterone (Item No. 15273) and corticosterone (Item No. 16063).{41025} DOC is metabolized to the neuroactive compound (3α,5α)-2,21-dihydroxypregnan-20-one (THDOC), which positively modulates GABAA receptors and produces effects similar to barbiturates in rats.{41027} Injections of naloxone (Item Nos. 15594
ISO60191) and corticotropin-releasing hormone (CRH) increase, while dexamethasone decreases, DOC in cynomolgus monkeys.{41026} DOC levels are increased 3.4-fold in obese and diabetic mice.{41025}

Size	25 mg
Shipping	dry ice
CAS Number	64-85-7
Molecular Formula	C₂₁H₃₀O₃
SMILES	O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(CO)=O)=C1
Molecular Weight	330,5
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2937.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.