HOP (human recombinant)

Proteins - Chaperones/Heat Shock Proteins

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Cat No: 22733

Proteins - Chaperones/heat Shock Proteins

HOP (Hsp70/Hsp90 Organizing Protein), also known as Stress-Induced Phosphoprotein 1 (STI1 or STIP1), acts as a co-chaperone to reversibly form a complex with Hsp70 and Hsp90 to assist in transfer of proteins between Hsp70 and Hsp90. The three tetratri...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

STIP1 STI renal carcinoma antigen NY-REN-11 Transformation-sensitive protein IEF SSP 3521

Product Overview:
HOP (Hsp70/Hsp90 Organizing Protein), also known as Stress-Induced Phosphoprotein 1 (STI1 or STIP1), acts as a co-chaperone to reversibly form a complex with Hsp70 and Hsp90 to assist in transfer of proteins between Hsp70 and Hsp90. The three tetratricopeptide repeat domains (TPR1, TPR2a, and TPR2b) act as binding regions, with TPR1 and TPR2B binding to Hsp70 and TPR2A binding to Hsp90. {39121} Highly conserved in Eukaryotes, it is closely related to the yeast STI1. HOP is both a nuclear and cytoplasmic protein, capable of travel between both. {39122} HOP has also been found to interact with several other proteins/complexes, including but not limited to: Hsc70, Hsp90α, Hsp90β, PACRG, METTL21B, FLCN, FNIP1, and FNIP2. {39123,39124,39125,39126,39127}

Size	50 µg
Shipping	dry ice
Formulation	50 mM HEPES, pH 8.0, with 150 mM sodium chloride
Purity	≥95% as estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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