Bexarotene-d4

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Bexarotene-d₄

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Cat No: 22610

Biochemicals - Isotopically Labeled Standards

Bexarotene-d4 is intended for use as an internal standard for the quantification of bexarotene (Item No. 11571) by GC- or LC-MS. Bexarotene is a high-affinity ligand for retinoid X receptors (RXRs) (EC50s = 28, 25, and 20 nM for RXRα, β, and γ, respec...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-benzoic acid-d4

Correlated keywords:

153559-49-0 LG100069 LGD1069 RO264455 RO-26-4455 SR11247 targret targretin targretyn targrexin deuterated deuterium LG-100069 1069 69 LGD-1069 SR-11247 RXRa RXRb RXRg RXR? RXR? MDR-1

Product Overview:
Bexarotene-d4 is intended for use as an internal standard for the quantification of bexarotene (Item No. 11571) by GC- or LC-MS. Bexarotene is a high-affinity ligand for retinoid X receptors (RXRs) (EC50s = 28, 25, and 20 nM for RXRα, β, and γ, respectively).{20758} It inhibits cell cycle progression, induces apoptosis, prevents or overcomes multidrug resistance through multidrug resistance protein 1 (MDR1), and blocks angiogenesis and metastasis, making it a promising chemopreventive agent against cancer.{20757,20760} Bexarotene also, through RXR activation, stimulates clearance of soluble β-amyloid, reduces plaque area, and reverses deficits related to Alzheimer’s disease in mice.{20759}

Size	1 mg
Shipping	dry ice
CAS Number	2182068-00-2
Molecular Formula	C₂₄H₂₄D₄O₂
SMILES	C=C(C1=C([2H])C([2H])=C(C(O)=O)C([2H])=C1[2H])C2=CC3=C(C=C2C)C(C)(C)CCC3(C)C
Molecular Weight	352,5
Formulation	A crystalline solid
Purity	≥99% deuterated forms (d1-d4)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.