740 Y-P

Confirm delete?

740 Y-P

Zoom

Cat No: 22598

Biochemicals - Small Molecule Activators

740 Y-P is a peptide activator of phosphatidylinositol 3-kinase (PI3K).{37145} It binds to the p85 N- and C-terminal SH2 domains of PI3K but not to GST or the N-terminal domain of phospholipase C (PLC) in an affinity purification assay. 740 Y-P is cel...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysyl-L-seryl-L-?-aspartylglycylglycyl-O-phosphono-L-tyrosyl-L-methionyl-L-?-aspartyl-L-methionyl-L-serine

Correlated keywords:

740YP 740YPDGFR 740Y-P U-251 87 pmTOR MMP9 PI3-K

Product Overview:
740 Y-P is a peptide activator of phosphatidylinositol 3-kinase (PI3K).{37145} It binds to the p85 N- and C-terminal SH2 domains of PI3K but not to GST or the N-terminal domain of phospholipase C (PLC) in an affinity purification assay. 740 Y-P is cell-permeable and stimulates mitogenesis in serum-starved C2 cells at a concentration of 50 μg/ml. This effect is abolished by treatment with 10 μM wortmannin (Item No. 10010591), a PI3K inhibitor, indicating 740 Y-P is interacting specifically with PI3K in cells. 740 Y-P also reverses inhibition of PI3K by schisandrin B in U251 and U87 melanoma cells, inducing expression of phosphorylated mammalian target of rapamycin (p-mTOR) and matrix metalloproteinase-9 (MMP-9).{37146}

Size	500 µg
Shipping	dry ice
CAS Number	1236188-16-1
Molecular Formula	C₁₄₁H₂₂₂N₄₃O₃₉PS₃
SMILES	[H]N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCCN)C(N
Molecular Weight	3270,7
Formulation	A crystalline solid
Purity	≥85%
Custom Code	3504.00
UNSPSC code	12352204

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.