Irinotecan-d10 (hydrochloride)

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Irinotecan-d₁₀ (hydrochloride)

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Cat No: 22566

Biochemicals - Isotopically Labeled Standards

Irinotecan-d10 is intended for use as an internal standard for the quantification of irinotecan (Item No. 14180) by GC- or LC-MS. Irinotecan, a derivative of the alkaloid camptothecin (Item No. 11694), functions as a prodrug that is converted by tiss...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate-2,2,3,3,4,4,5,5,6,6-d10, monohydrochloride

Correlated keywords:

718613-28-6 deuterated deuterium internal quantifies quantify quantification GC-MS GC/MS gas chromatography mass spectrometry LC-MS LC/MS liquid isotope DNA glucuronosyl SN38 anti-tumor antitumor topoisomerase-I metastatic camtosar campto U101440E CPT11

Product Overview:
Irinotecan-d10 is intended for use as an internal standard for the quantification of irinotecan (Item No. 14180) by GC- or LC-MS. Irinotecan, a derivative of the alkaloid camptothecin (Item No. 11694), functions as a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I.{21114, 21115} Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1.{22661, 22662} Formulations containing irinotecan demonstrate broad spectrum antitumor activity against metastatic colorectal cancer, small cell lung cancer, and several other solid tumors and have proven useful in radiation treatment of tumors by sensitizing tissue to radiation damage.{21114, 21115}

Size	500 µg
Shipping	dry ice
CAS Number	718612-62-5
Molecular Formula	C₃₃H₂₈D₁₀N₄O₆ • HCl
SMILES	O=C(OC1=CC=C(N=C(C(N2C3)=CC([C@@](O)(CC)C(OC4)=O)=C4C2=O)C3=C5CC)C5=C1)N(CC6)CCC6N7C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C7([2H])[2H].Cl
Molecular Weight	633,2
Formulation	A solid
Purity	≥95% deuterated forms (d1-d10)
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.