Aloin

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Aloin

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Cat No: 22435

Aloin is a mixture of aloin A and aloin B (Item No. 23321), anthraquinones found in Aloe vera, and has diverse biological activities.{36960,36961,36962} It reduces IL-6 and TNF-α expression as well as nitric oxide (NO) production and COX-2 and inducib...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

10-?-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone

Correlated keywords:

1356655-05-4 8015-61-0 antiinflammatory anti oxidant cancer microbial mycobacterium low-density lipoprotein 2,2'-azobis(2-amidinopropane) IL6 TNF? 11678 Barbaloin

Product Overview:
Aloin is a mixture of aloin A and aloin B (Item No. 23321), anthraquinones found in Aloe vera, and has diverse biological activities.{36960,36961,36962} It reduces IL-6 and TNF-α expression as well as nitric oxide (NO) production and COX-2 and inducible NO synthase (iNOS) expression in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 100 to 400 mM.{36960} Aloin inhibits LPS-induced p65 acetylation, nuclear translocation of NF-kB, and apoptosis in RAW 264.7 cells. It reduces motility of T. congolense in vitro and reduces the number of parasites in T. congolense-infected mice when administered at a dose of 400 mg/kg.{36961} Aloin (50 and 100 mg/kg) also reduces activity of glutathione peroxidase (GPX), glutathione-S-transferase (GST), and glutathione reductase (GR), the level of colonic malondialdehyde (MDA), and the number of aberrant crypt foci and mucin-depleted foci in a rat model of 1,2-dimethylhydrazine-induced colon cancer.{36962}

Size	500 mg
Shipping	dry ice
CAS Number	452311-56-7
Molecular Formula	C₂₁H₂₂O₉
SMILES	O=C1C2=C(O)C=C(CO)C=C2C([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C4=C1C(O)=CC=C4
Molecular Weight	418,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.