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Nrf2 (N-Term) Polyclonal Antibody

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    Nrf2 (N-<wbr/>Term) Polyclonal Antibody
  • Nrf2 (N-<wbr/>Term) Polyclonal Antibody
Cat No: 14114

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor encoded by NFE2L2 in humans that regulates the cellular antioxidant response.{53865} It is a 605-amino acid protein comprised of seven highly conserved N...

: 1 ea

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • transcription factors heterodimer Maf ARE antioxidative Kelch ECH CUL3 Keap-1 Keap 1 ubiquination inflammatory NRF2 Nrf-2 NFE2-related factor 2 n-terminal nterm NF-E2-related factor 2 ferroptosis
Product Overview:
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor encoded by NFE2L2 in humans that regulates the cellular antioxidant response.{53865} It is a 605-amino acid protein comprised of seven highly conserved Nrf2-ECH (Neh) homology domains.{53866,53867} Nrf2 contains a large central domain that recruits transcriptional co-activators, mediates heterodimerization with the transcription factor Maf, and can be phosphorylated by GSK3 or the ubiquitin ligase adapter protein β-TrCP.{53867,53868} The Nrf2 central domain is flanked by an N-terminal Neh2 domain that binds the negative regulator Kelch-like ECH-associated protein 1 (Keap1; Item No. 32035) and a C-terminal Neh3 domain that is required for transactivation.{53867} Nrf2 is ubiquitously expressed and, under homeostatic conditions, associates with Keap1 in the cytoplasm, preventing Nrf2 nuclear translocation and promoting its ubiquitination and proteasomal degradation.{53866,53869} In the presence of xenobiotic electrophiles or oxidants, Keap1 releases Nrf2 which translocates to the nucleus, dimerizes with Maf, and induces the expression of a variety of cytoprotective genes that have antioxidant, anti-inflammatory, and metabolic functions.{53865,53870,53745} Nrf2 siRNA knockdown increases DNA-crosslinking and apoptosis induced by cisplatin (Item No. 13119) in A549 cancer cells, indicating that Nrf2 contributes to chemoresistance.{53871} Tumor Nrf2 levels are increased in patients with non-small cell lung cancer (NSCLC) and this increase is associated with poor overall survival.{53872} Cayman's Nrf2 (N-Term) Polyclonal Antibody can be used for flow cytometry (FC), immunocytochemistry (ICC), and Western blot (WB) applications. The antibody recognizes native and polyubiquitinated Nrf2 at 67 and 90 kDa, respectively, from human, mouse, and rat samples.
Size 1 ea
Shipping dry ice
Host Rabbit
Antigen Peptide from the N-terminal region of human Nrf2 protein


Formulation 500 µl of peptide affinity-purified IgG
Custom Code 3822.19
UNSPSC code 12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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