N-Formyl-Met-Leu-Phe

Biochemicals - Receptor Pharmacology

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Cat No: 21495

Biochemicals - Receptor Pharmacology

N-Formyl-Met-Leu-Phe (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPRs; Ki = 0.8 pM), which are mainly localized on polymorphonuclear and mononuclear phagocytes.{34517} Activation of FPRs by fMLF leads to cellular...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-formyl-L-methionyl-L-leucyl-L-phenylalanine

Correlated keywords:

75501-03-0 NSC350593 Nformylmetleuphe NT fMLF

Product Overview:
N-Formyl-Met-Leu-Phe (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPRs; Ki = 0.8 pM), which are mainly localized on polymorphonuclear and mononuclear phagocytes.{34517} Activation of FPRs by fMLF leads to cellular activation, which is characterized by cellular polarization, chemotaxis, and release of proteolytic enzymes.{34518} fMLF induces contractions in isolated guinea pig jejunum (EC50 = 11 nM), proximal colon (EC50 = 3.5 nM), and distal colon (EC50 = 2.2 nM).{34516} In vitro, fMLF induces neurotransmitter release from enteric motor neurons.

Size	25 mg
Shipping	dry ice
CAS Number	59880-97-6
Molecular Formula	C₂₁H₃₁N₃O₅S
SMILES	O=C(O)[C@@H](N([H])C([C@@H](N(C([C@@H](N(C=O)[H])CCSC)=O)[H])CC(C)C)=O)CC1=CC=CC=C1
Molecular Weight	437,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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