Cyclic ADP-Ribose (ammonium salt

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Cyclic ADP-Ribose (ammonium salt)

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Cat No: 21417

Biochemicals - More Biochemicals

Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.{12737, 11940, 20368, 34320, 34319} This second messenger is gener...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-?-D-ribofuranosyl-adenosine 5'-(trihydrogen diphosphate), intramol. P',5''-ester, diammonium salt

Correlated keywords:

143822-66-6 150155-83-2 1018828-36-8 cAPD CD-38 157 TRPM-2 ER ADPR 119340-53-3

Product Overview:
Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.{12737, 11940, 20368, 34320, 34319} This second messenger is generated via the cADP-ribose synthases CD38 and CD157.{20368, 34319, 34317} cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.{34318} In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with isoproterenol (Item No. 15592), and treatment with this metabolite at 100 µM under heat stress conditions induces the release of oxytocin (Item No. 11799) from the mouse hypothalamus.{34317, 34320}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₁₅H₁₉N₅O₁₃P₂ • 2NH₄
SMILES	N=C1C2=C(N3C=N2)N=CN1[C@@]4([H])[C@H](O)[C@H](O)[C@](COP(OP(OC[C@@]5([H])O[C@]3([H])[C@H](O)[C@@H]5O)([O-])=O)([O-])=O)([H])O4.[NH4+].[NH4+]
Molecular Weight	575,4
Formulation	A solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.