IL-1R Antagonist

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IL-1R Antagonist

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Cat No: 21349

Biochemicals - Receptor Pharmacology

IL-1R antagonist is a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88) that changes the interaction of MyD88 and IL-1 receptor type I (IL-1RI).{39170} In mouse lymphocytes and thymoma EL4 cells, IL-1R antagonist (≥10 μM) i...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-benzenepropanamide

Correlated keywords:

AS1 IL1R BB-loop TIR domain TLR4 IL1-RI AS-1 MyD-88 IL1RI EL-4 IL1b IL1? lipopolysaccharide toll-like receptor TLR-4 proinflammatory

Product Overview:
IL-1R antagonist is a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88) that changes the interaction of MyD88 and IL-1 receptor type I (IL-1RI).{39170} In mouse lymphocytes and thymoma EL4 cells, IL-1R antagonist (≥10 μM) inhibits IL-1β-activated phosphorylation of p38 MAP kinase, a process specifically mediated by disruption of IL-1RI/MyD88. However, it has no influence on LPS-mediated TLR4/MyD88 signaling in freshly isolated mouse lymphocytes (100 μM). IL-1R antagonist also attenuates IL-1β-induced fever (200 mg/kg) and Staphylococcal enterotoxin B (SEB)-induced pro-inflammatory cytokine production and toxicity in mice at doses between 2-6 mg.{39170, 39171}

Size	1 mg
Shipping	dry ice
CAS Number	566914-00-9
Molecular Formula	C₁₈H₂₆N₂O₂
SMILES	O=C(N[C@@H](C(C)C)C(N1CCCC1)=O)CCC2=CC=CC=C2
Molecular Weight	302,4
Formulation	A solution in ethanol
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.