TNP-ATP (triethylammonium salt)

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Cat No: 20902

Biochemicals - Ion Channel Modulation

TNP-ATP is a derivative of ATP and an antagonist at the purinergic receptor subtypes P2X1, P2X3, and P2X2/3 (IC50s = 6, 0.9, and 7 nM, respectively).{36447} It is selective for those receptor subtypes over P2X2, P2X4, and P2X7 receptors (IC50s = 2,000...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

((3a'R,4'R,6'R,6a'R)-4'-(6-amino-9H-purin-9-yl)-6'-(((((((hydroxyoxidophosphoryl)oxy)oxidophosphoryl)oxy)oxidophosphoryl)oxy)methyl)-2,6-dinitro-3a',4',6',6a'-tetrahydrospiro[cyclohexane-1,2'-furo[3,4-d][1,3]dioxole]-2,5-dien-4-ylidene)azinate, triethyltetraammonium salt

Correlated keywords:

1417343-82-8 61368-63-6 TNPATP P-2X P-2-X P-3X P-3-X P-2/3X P-2/3-X P-4X P-4-X P-7X P-7-X 1321-N1 1321-N-1 P2X-1 3 2/3 2 4 7

Product Overview:
TNP-ATP is a derivative of ATP and an antagonist at the purinergic receptor subtypes P2X1, P2X3, and P2X2/3 (IC50s = 6, 0.9, and 7 nM, respectively).{36447} It is selective for those receptor subtypes over P2X2, P2X4, and P2X7 receptors (IC50s = 2,000, 15,200, and >30,000 nM, respectively). TNP-ATP inhibits calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC50s = 10 and 62 nM, respectively).{36448} In a mouse model of visceral pain, TNP-ATP reduces acetic-acid induced writhing with an ED50 value of 6.35 µmol/kg. TNP-ATP is also a fluorescent probe for the activity of ATP-binding enzymes, such as insulin-degrading enzyme (IDE).{36449} It displays excitation/emission maxima of 403 and 547 nm, respectively, with a four-fold increase in fluorescence intensity and an emission shift to 538 nm when bound to IDE.

Size	5 mg
Shipping	dry ice
Molecular Formula	C₁₆H₁₃N₈O₁₉P₃ • 4C₆H₁₆N
SMILES	O=P(OP(OP(O)([O-])=O)([O-])=O)([O-])OC[C@@H]1[C@]2([H])[C@](OC3(C([N+]([O-])=O)=C/C(C=C3[N+]([O-])=O)=[N+]([O-])/[O-])O2)([H])[C@H](N4C=NC5=C4N=CN=C5N)O1.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC
Molecular Weight	1123
Formulation	A 10 mM solution in water
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.