Vilanterol

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Vilanterol

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Cat No: 20702

Biochemicals - Receptor Pharmacology

Vilanterol is an ultra-long acting β2-adrenoceptor agonist (ultra-LABA) that has 1,000-fold selectivity for β2 over other β-receptors (pEC50s = 6.4, 9.4, and 6.1 for β1, β2, and β3, respectively).{32607,36208} In addition to its potency and selectivit...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

?1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol

Correlated keywords:

?2-adrenoceptor b2-adrenoceptor GW642444 GW-642444M GW642444M GW-642444X GW642444X ultra-LABA ultraLABA GSK642444

Product Overview:
Vilanterol is an ultra-long acting β2-adrenoceptor agonist (ultra-LABA) that has 1,000-fold selectivity for β2 over other β-receptors (pEC50s = 6.4, 9.4, and 6.1 for β1, β2, and β3, respectively).{32607,36208} In addition to its potency and selectivity, vilanterol is characterized by rapid onset of activity and prolonged duration of action.{32607,32608} It is being evaluated in clinical trials for airway disorders, including chronic obstructive pulmonary disease. Vilanterol is most effective in respiratory disorders when combined with inhaled corticosteroids or long-acting muscarinic antagonists.{29503,32133}

Size	500 µg
Shipping	dry ice
CAS Number	503068-34-6
Molecular Formula	C₂₄H₃₃Cl₂NO₅
SMILES	ClC1=C(COCCOCCCCCCNC[C@H](O)C2=CC=C(O)C(CO)=C2)C(Cl)=CC=C1
Molecular Weight	486,4
Formulation	A solution in ethanol
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.