Azithromycin-d3

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Azithromycin-d₃

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Cat No: 20675

Azithromycin-d3 is intended for use as an internal standard for the quantification of azithromycin (Item No. 15004) by GC- or LC-MS. Azithromycin is a macrolide antibiotic.{22758} It is active against S. pneumoniae, S. aureus, N. gonorrhoeae, M. pneum...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-?-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-6-(methyl-d3)-11-[[3,4,6-trideoxy-3-(dimethylamino)-?-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one

Correlated keywords:

anti-biotic malaria AZM aruzilina arzomicin auricin polyketide azasite azadose azatril azee azenil azimin aziromycin azisara azithral azithrocin azitrocin azitromax aziwin aziwok azomycin aztrin CP62993 CP-62993 CP62,993 CP-62,993 durasite hemomycin macromycin macrozit sanhe setron shimen sumamed sumazid tobil tridosil tromix trozocina ultreon XZ-405 XZ405 XZ-450 XZ450 xithron xithrone zeto zi-factor zifin zistic zithromac zithromax Zithromax-IV zitrim zitrocin zitromax zythromax deuterated deuterium GC-MS GC/MS gases chromatography masses spectrometry LC-MS LC/MS isotope GCMS LCMS deuterated deuterium interleukin Streptococcus Neisseria Mycoplasma pneumonia Helicobacter Chlamydia Haemophilus Streptococcus Enterococcus TNF? IL1? IL6

Product Overview:
Azithromycin-d3 is intended for use as an internal standard for the quantification of azithromycin (Item No. 15004) by GC- or LC-MS. Azithromycin is a macrolide antibiotic.{22758} It is active against S. pneumoniae, S. aureus, N. gonorrhoeae, M. pneumoniae, H. pylori, C. trachomatis, and H. influenzae in vitro (MIC90s = S. pyogenes, S. pneumoniae, E. faecalis, or H. influenzae infection (ED50s = 0.78, 8.7, 12.7, and 30.3 mg/kg, respectively).{53594} It inhibits replication of severe acute respiratory coronavirus 2 (SARS-CoV-2), but not Middle East respiratory syndrome CoV (MERS-CoV), when used at concentrations of 5 and 10 µM.{57523} Azithromycin also decreases plasma levels of IL-6, TNF-α, and IL-1β and increases survival in a mouse model of LPS-induced sepsis when administered at a dose of 100 mg/kg.{53595} Formulations containing azithromycin have been used in the treatment of a variety of bacterial infections.

Size	1 mg
Shipping	dry ice
CAS Number	163921-65-1
Molecular Formula	C₃₈H₆₉D₃N₂O₁₂
SMILES	C[C@@H]([C@@H]([C@H](C(O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C)=O)C)O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@@]2(C)OC)[C@H]([C@](O)(C[C@H](CN1C([2H])([2H])[2H])C)C)O[C@@](O[C@H](C)C[C@@H]3N(C)C)([H])[C@@H]3O
Molecular Weight	752
Formulation	A solid
Purity	≥99% deuterated forms (d1-d3)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.