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Alsterpaullone

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    Alster<wbr/>paullone
  • Alster<wbr/>paullone
Cat No: 14428
Biochemicals - More Biochemicals
Cayman
€91.00
Price is excluding VAT and does not include packaging neither shipping

An ATP-competitive, selective inhibitor of Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25 and GSK3?/? with IC50 values of 35, 15, 200, 40, and 4 nM, respectively.
Alsterpaullone is a derivative of kenpaullone (Item No. 10010239), an ATP-competit...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one
  • 9-Nitropaullone
  • NSC 705701
Correlated keywords:
  • 959569-16-5
  • proteins
  • kinases
  • inhibitors
  • inhibits
  • inhibitions
  • cells
  • cycles
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Product Overview:
An ATP-competitive, selective inhibitor of Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25 and GSK3?/? with IC50 values of 35, 15, 200, 40, and 4 nM, respectively.
Alsterpaullone is a derivative of kenpaullone (Item No. 10010239), an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3? (GSK3?). With slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3?/? with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Alsterpaullone has been used to inhibit the cytosolic degradation of ?-catenin to alter the canonical Wnt signaling pathway in primary axis patterning, to reduce tau phosphorylation in an effort to modify neuropathological events associated with Alzheimer’s disease, and to alter cell proliferation or protein expression in various diseases.
Size 1 mg
Shipping wet ice
Stability Store at -20 degrees; shelf life 730 days maximum after production
CAS Number 237430-03-4
Molecular Formula C16H11N3O3
SMILES O=C1CC2=C(NC3=C2C=C([N+]([O-])=O)C=C3)C4=CC=CC=C4N1
Molecular Weight 293.3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933497050
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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