Fucoidan

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Fucoidan

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Cat No: 20357

Biochemicals - Ox Stress Reagents

Fucoidan is a sulfated polysaccharide that has been found in various brown algae species, including L. digitata, A. nodosum, M. pyrifera, and F. vesiculosus, and has diverse biological activities.{60475} Fucoidan consists of repeated (1→3)-L-fucopyran...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2S,3S,4S,5S,6R)-4-hydroxy-5-methoxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate

Correlated keywords:

1628783-15-2 sulfated polysaccharide antiviral neuroprotection mekabu fucoidan fucoidin fucoidine fuco’min nemacystus mucilage sea alga-f algae seaweed anti-cancer anti-viral neuro-protective nano-system

Product Overview:
Fucoidan is a sulfated polysaccharide that has been found in various brown algae species, including L. digitata, A. nodosum, M. pyrifera, and F. vesiculosus, and has diverse biological activities.{60475} Fucoidan consists of repeated (1→3)-L-fucopyranoses or alternating and repeated (1→3)- and (1→4)-L-fucopyranoses, as well as R groups composed of sulfate, uronic acid, or fucose groups. It also contains other sugars such as galactose. It has antioxidant activity in ferric reducing and DPPH (Item No. 14805) scavenging assays (IC50s = 76.8 and 93.69 µg/ml, respectively).{60476} Fucoidan inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication in Vero cells (IC50s = 2.5 and 2.6 µg/ml, respectively).{60477} It also inhibits thrombin-induced aggregation of isolated human platelets when used at a concentration of 100 µg/ml.{60478} Fucoidan (4 mg/kg) decreases neutrophil infiltration in a rat model of peptone-induced acute peritonitis. It reduces tumor growth, inhibits angiogenesis, and decreases the number of lung metastases in a 4T1 murine model of breast cancer when administered at doses of 5 and 10 mg/kg.{60479} Formulations containing fucoidan have been used as dietary supplements.

Size	250 mg
Shipping	dry ice
CAS Number	9072-19-9
Molecular Formula	(C₆H₉O₃SO₃)_n
SMILES	C[C@H]1O[C@H](OC2[C@H](C)O[C@@H](OC3[C@H](O[R])[C@H](C)O[C@@H](OC4[C@H](C)O[C@@H](C)[C@@H](O[R])[C@@H]4O[R])[C@H]3O[R])[C@@H](O[R])[C@@H]2O[R])[C@H](O[R])[C@@H](OC)[C@H]1O[R].CC.CC
Formulation	A crystalline solid
Purity	≥85%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.