m-Iodobenzylguanidine (hemisulfa

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m-Iodobenzylguanidine (hemisulfate)

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Cat No: 19998

Biochemicals - More Biochemicals

m-Iodobenzylguanidine (MIBG) is an analogue of norepinephrine with anticancer activity.{42768} It inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines when used at a concentration of 20 µg/m...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[(3-iodophenyl)methyl]-guanidine, hemisulfate

Correlated keywords:

80663-95-2 Iodo-benzylguanidine Iodobenzyl-guanidine anti-cancer L-1210 N1-E155 N1E-155

Product Overview:
m-Iodobenzylguanidine (MIBG) is an analogue of norepinephrine with anticancer activity.{42768} It inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines when used at a concentration of 20 µg/ml and reduces clonogenic survival of L1210 leukemia cells in a concentration-dependent manner. MIBG increases survival in N1E155 and L1210 mouse xenograft models when administered at doses of 40 and 20 mg/kg, respectively. It selectively accumulates in chromaffin tissues and tumors and formulations containing radiolabeled forms of MIBG have been used as imaging agents in the diagnosis and treatment of neuroendocrine tumors.{42769} MIBG also inhibits ADP-ribose linkage to membrane proteins in turkey erythrocyte membranes.

Size	1 mg
Shipping	dry ice
CAS Number	87862-25-7
Molecular Formula	C₈H₁₀IN₃ • 1/2H₂SO₄
SMILES	IC1=CC=CC(CNC(N)=N)=C1.O=S(O)(O)=O
Molecular Weight	324,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.