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BRD6688

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    BRD6688
  • BRD6688
Cat No: 19836
Biochemicals - Small Molecule Inhibitors
Cayman

BRD6688 is an HDAC inhibitor with IC50 values of 21 nM, 100 nM, and 11.48 µM for HDAC1, 2, and 3, respectively.{32059} It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1 (381 min versus 65 min).{3205...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N-[2-amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide
Correlated keywords:
  • HDAC2 BRD-6688 histone deacetylase HDAC1 HDAC3 HDAC 1 2 3 kinetic
Product Overview:
BRD6688 is an HDAC inhibitor with IC50 values of 21 nM, 100 nM, and 11.48 µM for HDAC1, 2, and 3, respectively.{32059} It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1 (381 min versus 65 min).{32059} BRD6688 crosses the blood brain barrier and has been shown to rescue the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration.{32059}
Size 1 mg
Shipping dry ice
CAS Number 1404562-17-9
Molecular Formula C16H18N4O
SMILES O=C(N1CCCC1)NC2=CC(C3=CC=NC=C3)=CC=C2N
Molecular Weight 282,3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.39
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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