Benzbromarone

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Benzbromarone

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Cat No: 19768

Biochemicals - Small Molecule Inhibitors

Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption.{31716} It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-methanone

Correlated keywords:

uricosuric xanthine oxidase CYP2C9 CYP-2C9 CYP-2C-9 URAT1 URAT-1 urate anion azubromaron nesuric desuric minuric NSC85433 narcaricin normurat uricovac urinorm benzbromaron max-uric maxuric 3,5-dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl ketone L 2214 L2214 L2214-labaz L2214labaz MJ 10061 hURAT-1 P-450 CYP4502C9 CYP-4502C9 CYP450-2C9 transporter

Product Overview:
Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption.{31716} It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents.{24422} Several analogs of benzabromarone have been developed with varying binding affinities to CYP2C9 in order to study adverse drug-drug interactions.{24411}

Size	500 mg
Shipping	dry ice
CAS Number	3562-84-3
Molecular Formula	C₁₇H₁₂Br₂O₃
SMILES	BrC1=C(O)C(Br)=CC(C(C2=C(CC)OC3=C2C=CC=C3)=O)=C1
Molecular Weight	424,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2908.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.