(2R)-Octyl-?-hydroxyglutarate-d1

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(2R)-Octyl-?-hydroxyglutarate-d₁₇

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Cat No: 19694

Biochemicals - Isotopically Labeled Standards

α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent stu...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2R-hydroxy-pentanedioic acid, 1-octyl-d17 ester

Correlated keywords:

1391194-67-4 1391068-16-8 deuterated deuterium GCMS LCMS 2HG D2 L2 hydroxy-glutarate neuro-metabolic IDH-1 2 D2HG

Product Overview:
α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} (2R)-Octyl-α-hydroxyglutarate-d17 is intended for use as an internal standard for the quantification of (2R)-octyl-α-hydroxyglutarate (Item No. 16366) by GC- or LC-MS. (2R)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the D-isomer of 2-HG. It has been used to examine the contribution of D-2-HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells.{28419}

Size	500 µg
Shipping	dry ice
CAS Number	2748638-78-8
Molecular Formula	C₁₃H₇D₁₇O₅
SMILES	OC(CC[C@@H](O)C(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=O
Molecular Weight	277,4
Formulation	A crystalline solid
Purity	≥99% deuterated forms (d1-d17)
Custom Code	3822.19
UNSPSC code	12352100

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(2R)-Octyl-?-hydroxyglutarate-d17