6-Formylindolo[3,2-b]carbazole

Biochemicals - Small Molecule Activators

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Cat No: 19529

Biochemicals - Small Molecule Activators

6-Formylindolo[3,2-b]carbazole (FICZ) is a degradation product of tryptophan upon exposure to visible light that activates the aryl hydrocarbon receptor (AhR; Kd = 70 pM).{31887} This endogenous AhR ligand is also a good substrate for cytochromes P450...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5,11-dihydro-indolo[3,2-b]carbazole-6-carboxaldehyde

Correlated keywords:

ligand xenobiotic aryl hydrocarbon AhR CYP1A1 CYP1A2 CYP1B1 Ah-R P450CYP Ah-R P450CYP1A1 P450CYP1A2 P450CYP1A3

Product Overview:
6-Formylindolo[3,2-b]carbazole (FICZ) is a degradation product of tryptophan upon exposure to visible light that activates the aryl hydrocarbon receptor (AhR; Kd = 70 pM).{31887} This endogenous AhR ligand is also a good substrate for cytochromes P450 (CYP) 1A1, 1A2, and 1B1 (Kis = 15.4, 3.9, and 13.3 µM, respectively).{31888} When activated by either environmental toxins or endogenous ligands, the AhR induces detoxifying enzymes and modulates immune cell differentiation. FICZ has been used to study the immunomodulatory and host defense mechanisms of AhR signaling pathways.{27028}

Size	500 µg
Shipping	dry ice
CAS Number	172922-91-7
Molecular Formula	C₁₉H₁₂N₂O
SMILES	[H]C(C1=C2C(C(C=CC=C3)=C3N2)=CC4=C1C(C=CC=C5)=C5N4)=O
Molecular Weight	284,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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