N-(n-Butyl)deoxygalactonojirimyc

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N-(n-Butyl)deoxygalactonojirimycin

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Cat No: 19520

Biochemicals - Small Molecule Inhibitors

N-(n-Butyl)deoxygalactonojirimycin (NB-DGJ) is an inhibitor of the glycolipid biosynthesis enzyme glucosylceramide synthase and the glycolipid catabolic enzymes glucocerebrosidase (GBA) and β-glucosidase 2 (GBA2).{31624,49490,49491,49492,50926} It als...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-butyl-2R-(hydroxymethyl)-3S,4R,5S-piperidinetriol

Correlated keywords:

glucosyl ceramide NBDGJ GBA-2 HL60 WEHI3B Glb-1 GM-1

Product Overview:
N-(n-Butyl)deoxygalactonojirimycin (NB-DGJ) is an inhibitor of the glycolipid biosynthesis enzyme glucosylceramide synthase and the glycolipid catabolic enzymes glucocerebrosidase (GBA) and β-glucosidase 2 (GBA2).{31624,49490,49491,49492,50926} It also inhibits acid α-glucosidase, sucrase, maltase, and lactase.{49492} NB-DGJ (0.5-500 µM) reduces glycolipid levels in HL-60 and WEHI-3B cells.{31624} It decreases brain ganglioside levels in a Glb1-/- neonatal mouse model of GM1 gangliosidosis when administered intraperitoneally at doses of 600 and 1,200 mg/kg four times per day for three days.{31622} NB-DGJ (1-1,200 mg/kg per day for 35 days) increases testicular glucosylceramide levels in mice.{49490} NB-DGJ induces abnormal spermatid and acrosome formation, as well as reduces motility, in isolated mouse epididymal sperm when administered at doses of 15, 25, and 50 mg/kg per day.{50926} It also induces infertility, an effect that is reversed by withdrawal, in the same model.

Size	500 µg
Shipping	dry ice
CAS Number	141206-42-0
Molecular Formula	C₁₀H₂₁NO₄
SMILES	OC[C@H]1N(CCCC)C[C@H](O)[C@@H](O)[C@H]1O
Molecular Weight	219,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.39
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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