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Phomopsin A

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    Phomopsin A
  • Phomopsin A
Cat No: 19448
Biochemicals - Toxins
Cayman

Phomopsins are a family of mycotoxins produced by the fungus D. toxica, which predominantly infects lupines. Ingestion of lupines infected with D. toxica causes lupinosis, a degenerative disorder that can result in acute liver damage, brain damage, and...

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Territorial Availability: Available through Bertin Technologies only in France
Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.
Special Advice: Please check regulation status before ordering; additionel fees can apply.
Synonyms:
  • (2E)-(?S)-3-chloro-?,5-dihydroxy-N-methyl-L-tyrosyl-3,4-didehydro-L-valyl-3-hydroxy-L-isoleucyl-3,4-didehydro-L-prolyl-(2E)-2,3-didehydroisoleucyl-2,3-didehydro-aspartic acid, cyclic (15?3)-ether
Correlated keywords:
  • 126061-16-3 mycotoxin NSC381839 ?-tubulin b-tubulin hexapeptide diaporthe
Product Overview:
Phomopsins are a family of mycotoxins produced by the fungus D. toxica, which predominantly infects lupines. Ingestion of lupines infected with D. toxica causes lupinosis, a degenerative disorder that can result in acute liver damage, brain damage, and death.{31104} Phomopsin A is a cyclic hexapeptide mycotoxin that binds β-tubulin in a vinca domain, overlapping with the site targeted by vinblastine (Item No. 11762) and other tubulin inhibitors.{31105,31103} It binds β-tubulin from higher organisms but not α-tubulin or fungal mycelial tubulin.{31106,31107} Phomopsin A blocks microtubule growth, modulates the dynamics of microtubules, and interferes with mitosis.{31107}
Size 1 mg
Shipping dry ice
CAS Number 64925-80-0
Molecular Formula C36H45ClN6O12
SMILES OC(/C(NC(/C(NC([C@H]1N(C([C@@H]2NC([C@H](C(C)=C)NC([C@@H](NC)[C@H](C3=CC(O[C@@]2(CC)C)=C(O)C(Cl)=C3)O)=O)=O)=O)CC=C1)=O)=C(CC)/C)=O)=C\C(O)=O)=O
Molecular Weight 789,2
Formulation A solid
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

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