Flavoxate (hydrochloride)

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Cat No: 19096

Biochemicals - Ion Channel Modulation

Flavoxate is an inhibitor of L-type calcium channels and an antimuscarinic agent.{30978} It induces relaxation of potassium-precontracted isolated human urinary bladder detrusor muscle (IC50 = 2 µM) and reduces contractions induced by the acetylcholin...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester, monohydrochloride

Correlated keywords:

15301-69-6 DW 61 DW61 genurin NSC114649 patricin peflate piperidinoethyl-3-methylflavone-8-carboxylate rec7/0040 rec70040 70040 rec spasmal spasuret urispas Cav1.2 Cav12 Cav-1.2 Cav-12 L-type Ltype calcium muscarinic acetylcholine overactive bladder muscle relaxant bladderon anticholinergic anti-cholinergic urinary spasm

Product Overview:
Flavoxate is an inhibitor of L-type calcium channels and an antimuscarinic agent.{30978} It induces relaxation of potassium-precontracted isolated human urinary bladder detrusor muscle (IC50 = 2 µM) and reduces contractions induced by the acetylcholine receptor agonist carbachol (carbamoylcholine; Item No. 14486) or calcium in isolated rat detrusor strips.{30978,57774} Microinjection of flavoxate (0.68 µg/animal) into the oral pontine reticular nucleus inhibits reflex micturition in decerebrated cats, and intravenous or intracerebroventricular administration reduces isovolumetric rhythmic bladder contractions in rats.{57774} Formulations containing flavoxate have previously been used in the treatment of frequent or urgent urination, increased nocturnal urination, bladder pain, and urinary incontinence.

Size	5 mg
Shipping	dry ice
CAS Number	3717-88-2
Molecular Formula	C₂₄H₂₅NO₄ • HCl
SMILES	CC1=C(C2=CC=CC=C2)OC3=C(C(OCCN4CCCCC4)=O)C=CC=C3C1=O.Cl
Molecular Weight	427,9
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.