RB394

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RB394

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Cat No: 18909

Biochemicals - Receptor Pharmacology

RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC50 of 0.33 µM and activates PPARγ with an EC50 of 0.3 µM.{31308} It is inactive at PPARδ and shows 29% activation of PPARα, relati...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

?-ethyl-4-[[[[4-methoxy-2-(trifluoromethyl)phenyl]methyl]amino]carbonyl]-benzenepropanoic acid

Correlated keywords:

PPAR? PPARy sEH soluble epoxide hydrolase CAY10702 RB-394

Product Overview:
RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC50 of 0.33 µM and activates PPARγ with an EC50 of 0.3 µM.{31308} It is inactive at PPARδ and shows 29% activation of PPARα, relative to control, at 10 µM.{31308} RB394 is water soluble, orally bioavailable, and can be delivered through drinking water. In a two week in vivo pharmacokinetic study in mice, 30 mg/kg body weight in drinking water resulted in a final plasma concentration of ~3 µM.{31308} This coincided with upregulation of PPARγ target genes, as well as PPARα and PPARδ, in mouse livers.{31308}

Size	1 mg
Shipping	dry ice
CAS Number	1830320-32-5
Molecular Formula	C₂₁H₂₂F₃NO₄
SMILES	COC1=CC(C(F)(F)F)=C(CNC(C2=CC=C(CC(C(O)=O)CC)C=C2)=O)C=C1
Molecular Weight	409,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.