Tolazoline (hydrochloride)

Biochemicals - Receptor Pharmacology

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Cat No: 18865

Biochemicals - Receptor Pharmacology

Tolazoline is an α1-adrenergic receptor (α1-AR; IC50 = 3,200 nM) and α2-AR antagonist (Kis = 112, 1,230, 354, and 173 nM for α2A, α2B-, α2C-, and α2D-ARs, respectively).{52937,30610} Tolazoline inhibits α-AR agonist-induced contractions in isolated hu...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4,5-dihydro-2-(phenylmethyl)-1H-imidazole, monohydrochloride

Correlated keywords:

7380-28-1 245547-27-7 59-98-3 benzazoline ?2-adrenergic a2-adrenergic HCl

Product Overview:
Tolazoline is an α1-adrenergic receptor (α1-AR; IC50 = 3,200 nM) and α2-AR antagonist (Kis = 112, 1,230, 354, and 173 nM for α2A, α2B-, α2C-, and α2D-ARs, respectively).{52937,30610} Tolazoline inhibits α-AR agonist-induced contractions in isolated human corpus cavernosum smooth muscle (IC50 = 0.1 µM).{52935} It also lowers vascular resistance in isolated perfused porcine skin flaps (IPPSFs) preconstricted by norepinephrine with an EC50 value of 288 nM.{52936} Formulations containing tolazoline have been used in veterinary medicine to reverse the analgesia and sedation induced by xylazine in horses.

Size	5 g
Shipping	dry ice
CAS Number	59-97-2
Molecular Formula	C₁₀H₁₂N₂ • HCl
SMILES	C1(CC2=NCCN2)=CC=CC=C1.Cl
Molecular Weight	196,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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