CGP 35348

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CGP 35348

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Cat No: 18599

Biochemicals - Receptor Pharmacology

The amino acid γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC, and a G protein-coupled receptor, GABAB. CGP 35348 is a selective, brain-accessible GA...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

P-?(3-?aminopropyl)?-?P-?(diethoxymethyl)?-phosphinic acid

Correlated keywords:

CGP35348 GABAB GABA-B g-aminobutyric ?-aminobutyric acid (3-aminopropyl)(diethoxymethyl)phosphinic

Product Overview:
The amino acid γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC, and a G protein-coupled receptor, GABAB. CGP 35348 is a selective, brain-accessible GABAB receptor antagonist (IC50 = 34 µM).{30403} It blocks the action of the GABAB-selective agonist baclofen (Item No. 18600) at postsynaptic sites but not at presynaptic receptors.{30403,30400} CGP 35348 prevents baclofen-induced antinociception and muscle relaxation in mice and rats.{30402} It is commonly used to investigate the role of GABAB activation in neurological signaling.{30401,30399,30398}

Size	10 mg
Shipping	wet ice
CAS Number	123690-79-9
Molecular Formula	C₈H₂₀NO₄P
SMILES	CCOC(OCC)P(CCCN)(O)=O
Molecular Weight	225,2
Formulation	A solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.