PF-04929113

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PF-04929113

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Cat No: 18270

Biochemicals - Small Molecule Inhibitors

PF-04929113 is a prodrug for the Hsp90 inhibitor, PF-04958473 (SNX-2112; Item No. 22359), which binds both Hsp90α and Hsp90β with an IC50 value of 30 nM.{31149,31150} The prodrug, PF-04929113, is rapidly absorbed and converted into the active inhibit...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

glycine, trans-4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl]amino]cyclohexyl ester

Correlated keywords:

1108208-66-7 snx5422 PF04929113 SNX5422 prodrug Hsp90 heat shock protein Hsp90? Hsp90? Hsp90a Hsp90b Hsp90i-2-PRO Hsp90i2PRO PF-4929113 PF4929113 Hsp-90 pro-drug Hsp90-? Hsp90-? Hsp90-a Hsp90-b Hsp90i2-PRO Hsp90i-2PRO PF04958473 SNX2112 PF-4958473 PF4958473 HER-2 ERK1 ERK2 ERK-1 ERK-2

Product Overview:
PF-04929113 is a prodrug for the Hsp90 inhibitor, PF-04958473 (SNX-2112; Item No. 22359), which binds both Hsp90α and Hsp90β with an IC50 value of 30 nM.{31149,31150} The prodrug, PF-04929113, is rapidly absorbed and converted into the active inhibitor after oral administration.{31150} The active inhibitor causes degradation of Hsp90 client proteins, including HER2, and reduces phosphorylation of downstream kinases, including Akt and ERK1/2, leading to apoptosis in cancer cells.{31149,31152} Oral administration of the prodrug, PF-04929113, reduces tumor growth and prolongs survival in mouse models of multiple myeloma and prostate cancer.{31152,31151}

Size	1 mg
Shipping	dry ice
CAS Number	908115-27-5
Molecular Formula	C₂₅H₃₀F₃N₅O₄
SMILES	O=C(CN)O[C@@H](CC1)CC[C@H]1NC2=CC(N3N=C(C(F)(F)F)C4=C3CC(C)(C)CC4=O)=CC=C2C(N)=O
Molecular Weight	521,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.