Donepezil-d4 (hydrochloride)

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Donepezil-d₄ (hydrochloride)

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Cat No: 18251

Biochemicals - Isotopically Labeled Standards

Donepezil-d4 is intended for use as an internal standard for the quantification of donepezil (Item No. 13245) by GC- or LC-MS. Donepezil is an inhibitor of acetylcholinesterase (AChE; IC50 = 6.7 nM).{58815} It is selective for AChE over butyrylcholine...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2,3-dihydro-5,6-dimethoxy-2[[1-(phenylmethyl-d2)-4-piperidinyl]methyl-d2]-1H-inden-1-one, monohydrochloride

Correlated keywords:

1219908-72-1 GCMS LCMS deuterated deuterium TNF? amyloid? A?O 1-42 Mac1 intra hippo campal

Product Overview:
Donepezil-d4 is intended for use as an internal standard for the quantification of donepezil (Item No. 13245) by GC- or LC-MS. Donepezil is an inhibitor of acetylcholinesterase (AChE; IC50 = 6.7 nM).{58815} It is selective for AChE over butyrylcholinesterase (BChE; IC50 = 988 nM). Donepezil (0.1 and 1 µM) inhibits the production of nitric oxide (NO) and TNF-α induced by oligomeric amyloid-β (1-42) (AβO1-42) in primary rat microglial cells.{58816} It increases ACh levels in the cortex and hippocampus of aged rats when administered at a dose of 1.5 mg/kg.{58817} Donepezil (2 mg/kg) reduces Mac-1 and GFAP protein expression, markers of microglia and astrocyte activation, respectively, in the hippocampal dentate gyrus of a mouse model of Alzheimer’s disease induced by intrahippocampal injection of AβO1-42.{58816} It increases step-through latency in a passive avoidance test in the same model. Formulations containing donepezil have been used in the treatment of Alzheimer’s disease.

Size	500 µg
Shipping	dry ice
CAS Number	1219798-88-5
Molecular Formula	C₂₄H₂₅D₄NO₃ • HCl
SMILES	O=C1C(C([2H])([2H])C2CCN(C([2H])([2H])C3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.Cl
Molecular Weight	420
Formulation	A crystalline solid
Purity	≥99% deuterated forms (d1-d4)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.