Hydrocortisone 21-hemisuccinate

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Hydrocortisone 21-hemisuccinate (sodium salt)

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Cat No: 18226

Biochemicals - Lipids

Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytok...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

21-(3-carboxy-1-oxopropoxy)-11?,17-dihydroxy-pregn-4-ene-3,20-dione, monosodium salt

Correlated keywords:

30678-79-6 2203-97-6 steroid stem cell research signal transduction receptor agonist nuclear intracelluar signaling inflammation immunology endocrinology biochemical cortisol hormone glucocorticoid anti-inflammatory antiinflammatory immunosuppressive culture derivative endogenous U4905 A-hydrocort Ahydrocort buccalsone corlan 21-sodium EF-corelan EFcortelan emi-corlin emicorlin flebocortide intracort nordicort oralsone solu-cortef solucortef soluglyc solu-glyc

Product Overview:
Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 µM for IL-6).{29361} It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.{29362}

Size	100 mg
Shipping	dry ice
CAS Number	125-04-2
Molecular Formula	C₂₅H₃₃O₈ • Na
SMILES	[H][C@]12[C@@]([C@@](CC[C@]3(O)C(COC(CCC([O-])=O)=O)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(CC[C@@]41C)=O.[Na+]
Molecular Weight	484,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2937.29
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.