CCT128930

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CCT128930

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Cat No: 18194

Biochemicals - Kinase Inhibitors

CCT128930 is an ATP-competitive inhibitor of Akt2 (IC50 = 6 nM).{29493} It is selective for Akt over a panel of 47 other kinases, including the related protein kinase A and p70S6K.{29493} CCT128930 blocks the phosphorylation of Akt targets, inhibits p...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine

Correlated keywords:

CCT-128930 Akt-2

Product Overview:
CCT128930 is an ATP-competitive inhibitor of Akt2 (IC50 = 6 nM).{29493} It is selective for Akt over a panel of 47 other kinases, including the related protein kinase A and p70S6K.{29493} CCT128930 blocks the phosphorylation of Akt targets, inhibits proliferation of multiple tumor cell lines in vitro, and prevents the growth of human tumor xenografts in mice.{29493} CCT128930 has been used to elucidate the role of Akt2 in regulating the function of interacting proteins, modulating DNA damage and autophagy in HepG2 hepatoma cells, and cell survival and vasculogenesis in endothelial colony forming cells.{29488,29492,29491}

Size	1 mg
Shipping	dry ice
CAS Number	885499-61-6
Molecular Formula	C₁₈H₂₀ClN₅
SMILES	ClC(C=C1)=CC=C1CC(CC2)(N)CCN2C3=C4C(NC=C4)=NC=N3
Molecular Weight	341,8
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.