?-Amanitin

Confirm delete?

?-Amanitin

Zoom

Cat No: 18142

Biochemicals - Small Molecule Inhibitors

β-Amanitin is a cyclic peptide found in several species of the Amanita genus, as well as other poisonous fungi.{29215} It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthe...

This article is not for sale online.
Contact us for more information about this article.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

                                            Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.
                    

                        Special Advice: Please check regulation status before ordering; additionel fees can apply. 
                    

Synonyms:

1-L-aspartic acid-?-amanitin

Correlated keywords:

13567-07-2 21373-31-9 amatoxin mycotoxin inhibitor RNA polymerase II III protein synthesis biochemical cell biology inhibit natural product peptide ?-amanitine

Product Overview:
β-Amanitin is a cyclic peptide found in several species of the Amanita genus, as well as other poisonous fungi.{29215} It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis.{29205,20588} The biological activity of this toxin is similar to that of α-amanitin (Item No. 17898) but differs structurally by the presence of a carboxyl group, which is useful for coupling reactions.{29216}

Size	1 mg
Shipping	dry ice
CAS Number	21150-22-1
Molecular Formula	C₃₉H₅₃N₉O₁₅S
SMILES	O=C(N[C@@]1([H])[C@@H](C)[C@@H](O)CO)[C@@]2([H])N(C[C@H](O)C2)C([C@H](CC(O)=O)NC([C@@]([H])(NC(CNC([C@@]([C@H](CC)C)([H])NC(CN3)=O)=O)=O)CS(C4=C(C(C=CC(O)=C5)=C5N4)C[C@@H](C3=O)NC1=O)=O)=O)=O
Molecular Weight	920
Formulation	A crystalline solid
Purity	≥90%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.