DDR1-IN-1 (hydrate)

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DDR1-IN-1 (hydrate)

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Cat No: 18092

Biochemicals - Kinase Inhibitors

The discoidin domain receptor (DDR) tyrosine kinases are activated by matrix collagens and are important for cell proliferation, differentiation, adhesion, migration, and invasion. DDR1-IN-1 binds to DDR1 and inhibits DDR1 autophosphorylation with an I...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzamide, hydrate

Correlated keywords:

1449685-96-4 1780303-76-5 DDR1 discoidin domain receptor 1 DDR1IN1 DDR 2705545-92-0

Product Overview:
The discoidin domain receptor (DDR) tyrosine kinases are activated by matrix collagens and are important for cell proliferation, differentiation, adhesion, migration, and invasion. DDR1-IN-1 binds to DDR1 and inhibits DDR1 autophosphorylation with an IC50 value of 105 nM and an EC50 value of 87 nM.{29876,29875} It demonstrates weaker inhibition for DDR2 (IC50 = 413 nM) and has a good selectivity profile against a panel of 451 kinases.{29876} DDR-IN-1 has been shown to inhibit colorectal cancer cell lines when used in combination with the PI3K/mTOR inhibitor, GSK2126458 (Item No. 17377).{29876}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₃₀H₃₁F₃N₄O₃ • XH₂O
SMILES	O=C(NC1=CC=C(C)C(OC2=CC3=C(NC(C3)=O)C=C2)=C1)C4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4.O
Molecular Weight	552,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.59
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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